Question 11

The drop in serum creatinine during pregnancy to a range of 0.4-0.8 mg/dl is caused by what physiologic change in kidney function?

Answer Choices:

Increased glomerular filtration rate (GFR)

Decreased GFR

Increased plasma osmolality

Decreased renal plasma flow

Correct Answer:

Increased glomerular filtration rate (GFR)

Explanation:

  • The physiologic increase in glomerular filtration rate (GFR) in pregnancy normally results in a decrease in the concentration of serum creatinine to a range of 0.4 to 0.8 mg/dl. The fall in serum creatinine also reflects hemodilution from the 30-50% plasma volume expansion in pregnancy.